Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High-Fat Diet-Fed Mice.
Identifieur interne : 000199 ( Main/Exploration ); précédent : 000198; suivant : 000200Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High-Fat Diet-Fed Mice.
Auteurs : Nicolas Cardinault [France] ; Franck Tourniaire [France] ; Julien Astier [France] ; Charlène Couturier [France] ; Estelle Perrin [France] ; Julie Dalifard [France] ; Eva Seipelt [France] ; Lourdes Mounien [France] ; Claire Letullier [France] ; Lauriane Bonnet [France] ; Esma Karkeni [France] ; Naïma Delbah [France] ; Stéphane Georgé [France] ; Jean-François Landrier [France]Source :
- Molecular nutrition & food research [ 1613-4133 ] ; 2020.
Abstract
SCOPE
Current evidence supports the beneficial effect of polyphenols on the management of obesity and associated comorbidities. This is the case for propolis, a polyphenol-rich substance produced by bees. The aim of the present study is to evaluate the effect of a poplar propolis ethanolic extract (PPEE) on obesity and glucose homeostasis, and to unveil its putative molecular mechanisms of action.
METHODS AND RESULTS
Male high-fat (HF) diet-fed mice are administered PPEE for 12 weeks. PPEE supplementation reduces the HF-mediated adiposity index, adipocyte hypertrophy, and body weight gain. It also improves HOMA-IR and fasting glucose levels. Gene expression profiling of adipose tissue (AT) shows an induction of mRNA related to lipid catabolism and mitochondrial biogenesis and inhibition of mRNA coding for inflammatory markers. Interestingly, several Nrf2-target genes are induced in AT following administration of PPEE. The ability of PPEE to induce the expression of Nrf2-target genes is studied in adipocytes. PPEE is found to transactivate the Nrf2 response element and the Nrf2 DNA-binding, suggesting that part of the effect of PPEE can be mediated by Nrf2.
CONCLUSION
PPEE supplementation may represent an interesting preventive strategy to tackle the onset of obesity and associated metabolic disorders.
DOI: 10.1002/mnfr.202000275
PubMed: 32729164
Affiliations:
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d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Karkeni, Esma" sort="Karkeni, Esma" uniqKey="Karkeni E" first="Esma" last="Karkeni">Esma Karkeni</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Delbah, Naima" sort="Delbah, Naima" uniqKey="Delbah N" first="Naïma" last="Delbah">Naïma Delbah</name><affiliation wicri:level="3"><nlm:affiliation>CTCPA, 449 Avenue Clément Ader, Avignon, 84911, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CTCPA, 449 Avenue 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xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32729164</idno><idno type="pmid">32729164</idno><idno type="doi">10.1002/mnfr.202000275</idno><idno type="wicri:Area/Main/Corpus">000164</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000164</idno><idno type="wicri:Area/Main/Curation">000164</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000164</idno><idno type="wicri:Area/Main/Exploration">000164</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High-Fat Diet-Fed Mice.</title><author><name sortKey="Cardinault, Nicolas" sort="Cardinault, Nicolas" uniqKey="Cardinault N" first="Nicolas" last="Cardinault">Nicolas Cardinault</name><affiliation wicri:level="3"><nlm:affiliation>Pollenergie, La Grabère, Saint Hilaire de Lusignan, 47450, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pollenergie, La Grabère, Saint Hilaire de Lusignan, 47450</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Tourniaire, Franck" sort="Tourniaire, Franck" uniqKey="Tourniaire F" first="Franck" last="Tourniaire">Franck Tourniaire</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Astier, Julien" sort="Astier, Julien" uniqKey="Astier J" first="Julien" last="Astier">Julien Astier</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Couturier, Charlene" sort="Couturier, Charlene" uniqKey="Couturier C" first="Charlène" last="Couturier">Charlène Couturier</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Perrin, Estelle" sort="Perrin, Estelle" uniqKey="Perrin E" first="Estelle" last="Perrin">Estelle Perrin</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Dalifard, Julie" sort="Dalifard, Julie" uniqKey="Dalifard J" first="Julie" last="Dalifard">Julie Dalifard</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Seipelt, Eva" sort="Seipelt, Eva" uniqKey="Seipelt E" first="Eva" last="Seipelt">Eva Seipelt</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Mounien, Lourdes" sort="Mounien, Lourdes" uniqKey="Mounien L" first="Lourdes" last="Mounien">Lourdes Mounien</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Letullier, Claire" sort="Letullier, Claire" uniqKey="Letullier C" first="Claire" last="Letullier">Claire Letullier</name><affiliation wicri:level="3"><nlm:affiliation>Pollenergie, La Grabère, Saint Hilaire de Lusignan, 47450, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pollenergie, La Grabère, Saint Hilaire de Lusignan, 47450</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Bonnet, Lauriane" sort="Bonnet, Lauriane" uniqKey="Bonnet L" first="Lauriane" last="Bonnet">Lauriane Bonnet</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Karkeni, Esma" sort="Karkeni, Esma" uniqKey="Karkeni E" first="Esma" last="Karkeni">Esma Karkeni</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Delbah, Naima" sort="Delbah, Naima" uniqKey="Delbah N" first="Naïma" last="Delbah">Naïma Delbah</name><affiliation wicri:level="3"><nlm:affiliation>CTCPA, 449 Avenue Clément Ader, Avignon, 84911, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CTCPA, 449 Avenue Clément Ader, Avignon, 84911</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="George, Stephane" sort="George, Stephane" uniqKey="George S" first="Stéphane" last="Georgé">Stéphane Georgé</name><affiliation wicri:level="3"><nlm:affiliation>CTCPA, 449 Avenue Clément Ader, Avignon, 84911, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CTCPA, 449 Avenue Clément Ader, Avignon, 84911</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Landrier, Jean Francois" sort="Landrier, Jean Francois" uniqKey="Landrier J" first="Jean-François" last="Landrier">Jean-François Landrier</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, Marseille, cedex 5 13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author></analytic><series><title level="j">Molecular nutrition & food research</title><idno type="eISSN">1613-4133</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>SCOPE</b></p><p>Current evidence supports the beneficial effect of polyphenols on the management of obesity and associated comorbidities. This is the case for propolis, a polyphenol-rich substance produced by bees. The aim of the present study is to evaluate the effect of a poplar propolis ethanolic extract (PPEE) on obesity and glucose homeostasis, and to unveil its putative molecular mechanisms of action.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND RESULTS</b></p><p>Male high-fat (HF) diet-fed mice are administered PPEE for 12 weeks. PPEE supplementation reduces the HF-mediated adiposity index, adipocyte hypertrophy, and body weight gain. It also improves HOMA-IR and fasting glucose levels. Gene expression profiling of adipose tissue (AT) shows an induction of mRNA related to lipid catabolism and mitochondrial biogenesis and inhibition of mRNA coding for inflammatory markers. Interestingly, several Nrf2-target genes are induced in AT following administration of PPEE. The ability of PPEE to induce the expression of Nrf2-target genes is studied in adipocytes. PPEE is found to transactivate the Nrf2 response element and the Nrf2 DNA-binding, suggesting that part of the effect of PPEE can be mediated by Nrf2.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>PPEE supplementation may represent an interesting preventive strategy to tackle the onset of obesity and associated metabolic disorders.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32729164</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1613-4133</ISSN><JournalIssue CitedMedium="Internet"><Volume>64</Volume><Issue>18</Issue><PubDate><Year>2020</Year><Month>09</Month></PubDate></JournalIssue><Title>Molecular nutrition & food research</Title><ISOAbbreviation>Mol Nutr Food Res</ISOAbbreviation></Journal><ArticleTitle>Poplar Propolis Ethanolic Extract Reduces Body Weight Gain and Glucose Metabolism Disruption in High-Fat Diet-Fed Mice.</ArticleTitle><Pagination><MedlinePgn>e2000275</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mnfr.202000275</ELocationID><Abstract><AbstractText Label="SCOPE">Current evidence supports the beneficial effect of polyphenols on the management of obesity and associated comorbidities. This is the case for propolis, a polyphenol-rich substance produced by bees. The aim of the present study is to evaluate the effect of a poplar propolis ethanolic extract (PPEE) on obesity and glucose homeostasis, and to unveil its putative molecular mechanisms of action.</AbstractText><AbstractText Label="METHODS AND RESULTS">Male high-fat (HF) diet-fed mice are administered PPEE for 12 weeks. PPEE supplementation reduces the HF-mediated adiposity index, adipocyte hypertrophy, and body weight gain. It also improves HOMA-IR and fasting glucose levels. Gene expression profiling of adipose tissue (AT) shows an induction of mRNA related to lipid catabolism and mitochondrial biogenesis and inhibition of mRNA coding for inflammatory markers. Interestingly, several Nrf2-target genes are induced in AT following administration of PPEE. The ability of PPEE to induce the expression of Nrf2-target genes is studied in adipocytes. PPEE is found to transactivate the Nrf2 response element and the Nrf2 DNA-binding, suggesting that part of the effect of PPEE can be mediated by Nrf2.</AbstractText><AbstractText Label="CONCLUSION">PPEE supplementation may represent an interesting preventive strategy to tackle the onset of obesity and associated metabolic disorders.</AbstractText><CopyrightInformation>© 2020 Wiley-VCH GmbH.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cardinault</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Pollenergie, La Grabère, Saint Hilaire de Lusignan, 47450, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tourniaire</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Astier</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couturier</LastName><ForeName>Charlène</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perrin</LastName><ForeName>Estelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalifard</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seipelt</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mounien</LastName><ForeName>Lourdes</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Letullier</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pollenergie, La Grabère, Saint Hilaire de Lusignan, 47450, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonnet</LastName><ForeName>Lauriane</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karkeni</LastName><ForeName>Esma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delbah</LastName><ForeName>Naïma</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>CTCPA, 449 Avenue Clément Ader, Avignon, 84911, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Georgé</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CTCPA, 449 Avenue Clément Ader, Avignon, 84911, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landrier</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><Identifier Source="ORCID">0000-0002-8690-8014</Identifier><AffiliationInfo><Affiliation>Aix-Marseille Université, C2VN, INRAE, INSERM, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, 27 Bd Jean Moulin, Marseille, cedex 5 13385, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Mol Nutr Food Res</MedlineTA><NlmUniqueID>101231818</NlmUniqueID><ISSNLinking>1613-4125</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">NRF2</Keyword><Keyword MajorTopicYN="Y">adipose tissue</Keyword><Keyword MajorTopicYN="Y">insulin resistance</Keyword><Keyword MajorTopicYN="Y">obesity</Keyword><Keyword MajorTopicYN="Y">propolis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Ther. 2008, 325, 655.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li><li>Provence-Alpes-Côte d'Azur</li></region><orgName><li>Université d'Aix-Marseille</li></orgName></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Cardinault, Nicolas" sort="Cardinault, Nicolas" uniqKey="Cardinault N" first="Nicolas" last="Cardinault">Nicolas Cardinault</name></region><name sortKey="Astier, Julien" sort="Astier, Julien" uniqKey="Astier J" first="Julien" last="Astier">Julien Astier</name><name sortKey="Bonnet, Lauriane" sort="Bonnet, Lauriane" uniqKey="Bonnet L" first="Lauriane" last="Bonnet">Lauriane Bonnet</name><name sortKey="Couturier, Charlene" sort="Couturier, Charlene" uniqKey="Couturier C" first="Charlène" last="Couturier">Charlène Couturier</name><name sortKey="Dalifard, Julie" sort="Dalifard, Julie" uniqKey="Dalifard J" first="Julie" last="Dalifard">Julie Dalifard</name><name sortKey="Delbah, Naima" sort="Delbah, Naima" uniqKey="Delbah N" first="Naïma" last="Delbah">Naïma Delbah</name><name sortKey="George, Stephane" sort="George, Stephane" uniqKey="George S" first="Stéphane" last="Georgé">Stéphane Georgé</name><name sortKey="Karkeni, Esma" sort="Karkeni, Esma" uniqKey="Karkeni E" first="Esma" last="Karkeni">Esma Karkeni</name><name sortKey="Landrier, Jean Francois" sort="Landrier, Jean Francois" uniqKey="Landrier J" first="Jean-François" last="Landrier">Jean-François Landrier</name><name sortKey="Landrier, Jean Francois" sort="Landrier, Jean Francois" uniqKey="Landrier J" first="Jean-François" last="Landrier">Jean-François Landrier</name><name sortKey="Letullier, Claire" sort="Letullier, Claire" uniqKey="Letullier C" first="Claire" last="Letullier">Claire Letullier</name><name sortKey="Mounien, Lourdes" sort="Mounien, Lourdes" uniqKey="Mounien L" first="Lourdes" last="Mounien">Lourdes Mounien</name><name sortKey="Perrin, Estelle" sort="Perrin, Estelle" uniqKey="Perrin E" first="Estelle" last="Perrin">Estelle Perrin</name><name sortKey="Seipelt, Eva" sort="Seipelt, Eva" uniqKey="Seipelt E" first="Eva" last="Seipelt">Eva Seipelt</name><name sortKey="Tourniaire, Franck" sort="Tourniaire, Franck" uniqKey="Tourniaire F" first="Franck" last="Tourniaire">Franck Tourniaire</name><name sortKey="Tourniaire, Franck" sort="Tourniaire, Franck" uniqKey="Tourniaire F" first="Franck" last="Tourniaire">Franck Tourniaire</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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